The volume provides an account of the Philadelphia Yellow Fever epidemic in 1793, and is largely religious in nature. Entries describe the illness, as well as the death and burial of many members of Cresson’s community. The volume includes a note signed by Mary Cresson, Cresson's wife, which she addressed to their children, so that they would understand the circumstances of their father's death.

This collection is comprised of the papers of Isaac Proctor. The majority of the collection is composed of the personal correspondence of Proctor from the end of the 18th century, but also includes a single, small diary, and a single folder of his financial records.